Branded Medicine

 
CELOCID® 750

Injection powder

 
:: COMPOSITIONS ::

Each vial contains:
Cefuroxime as cefuroxime sodium 1 mg

 
:: INDICATIONS ::
  • Lower respiratory tract infections: acute and chronic bronchitis, infected bronchiectasis, bacterial pneumonia, lung abscess and postoperative chest infections.
  • Urinary tract infections: acute and chronic pyelonephritis, cystitis, asymptomatic bacteriuria.
  • Soft tissue infection: cellulitis, erysipelas, peritonitis and wound infections.
  • Bone and joint infection: osteomyelitis.
  • Obstetric and gynecological infection: pelvic inflammatory disease.
  • Gonorrhoea, particularly if penicillin is unsuitable.
  • Other infections: septicemia and meningitis.
  • Prophylaxis against infection in abdominal, pelvic, orthopedic, cardiac, pulmonary, esophageal and vascular surgery where there is increased risk from infection.
 
:: CONTRAINDICATIONS ::

Patients with known hypersensitivity to cephalosporin antibiotics.

 
:: DOSAGE AND ADMINISTRATIONS ::

General dosage
Adults: 
Many infections will respond to 750 mg three times daily by intramuscular or intravenous injection.
For more severe infections this dose should be increased to 1.5 gram three times daily intravenously.

Infants and children: 
Doses of 30 to 100 mg/kg/day given in 3 or 4 divided doses.
A dose of 60 mg/kg/day will be appropriate for most infections.

Neonates:
Doses of 30 to 100 mg/kg/day given in 2 or 3 divided doses.

Gonorrhoe:
1.5 gram should be given as a single dose or as two 750 mg injections into different sites.

Meningitis
Infants and children: 
150 to 250 mg/kg/day intravenously in 3 or 4 divided doses. This dosage may be reduced to 100 mg/kg/day after three days or when clinical improvement occurs.

Adults: 
3 gram intravenously every eight hours.

Prophylaxis
The usual dose is 1.5 gram intravenously with induction of anesthesia.
For orthopedic, pelvic and abdominal operations, this may be followed with two 750 mg doses 8 and 16 hours later.
For vascular, cardiac, esophageal and pulmonary operations this may be supplemented with 750 mg intramuscularly three times a day for a further 24 to 48 hours.

Dosage in impaired renal function
The dosage should be reduced to allow for slower excretion in patients with impaired renal function.

 
:: SPECIAL PRECAUTIONS ::
  • Patients who have experienced an anaphylactic reaction to penicillin.
  • Patients who receive high dosage of cephalosporin and use potent diuretics (such as furosemide) or aminoglycosides, as these combinations are suspected of adversely affecting renal function.
  • Pregnant and nursing patients.
  • Patients with gastrointestinal history, particularly colitis.
 
:: ADVERSE REACTIONS ::
  • Gastrointestinal disturbance: pseudomembranous colitis
  • Hypersensitivity reaction: skin rashes (maculopapular and urticarial), drug fever and anaphylaxis reaction.
  • Hematologic reactions: a decrease in hemoglobin concentration, eosinophilia, leukopenia and neutropenia.
  • Thrombophlebitis may occur at the site of intravenous injection.
 
:: PRESENTATION ::

CELOCID® 750. Vial @ 750 mg.