Branded Medicine

 
VOMETRAZ ®

Injection

 
:: COMPOSITIONS ::

Each ml contains:
Ondansetron HCl dihydrat 2.5 mg
equivalent with ondansetron base 2 mg

 
:: INDICATIONS ::

Management of nausea and vomiting induced by cytotoxic chemotherapy and radiotherapy, and operative.

 
:: CONTRAINDICATIONS ::

Patients who have known hypersensitivity to ondansetron.

 
:: DOSAGE AND ADMINISTRATION ::

Treatment of post-operative nausea and vomiting:
A single dose of 4 mg IM and 4 mg given by slow intravenous injection is recommended.

Prevention and treatment of nausea and vomiting induced by chemotherapy:
Adults:

  • Highly emetogenic chemotherapy:
    A dose of 8 mg by slow intravenous injection or as a short-time intravenous infusion over 15 minutes immediately before chemotherapy, followed by a constant infusion of 1 mg/hour for up to 24 hours or 2 further slow intravenous injection doses of 8 mg (over 15 minutes) 4 hours apart, or by oral administration is 8 mg twice daily should be continued for up to 5 days after a course of treatment.
  • Emetogenic chemotherapy:
    A dose of 8 mg by slow intravenous injection or as a short-time intravenous infusion over 15 minutes immediately before chemotherapy, followed by per oral 8 mg twice daily should be continued for up to 5 days after a course of treatment.

Children >4 years of age:
5 mg/ml by intravenous infusion over 15 minutes immediately before chemotherapy, followed by per oral 4 mg every 12 hours for less than 5 days.

Elderly:
Ondansetron is well tolerated by patients over 65 years and no alteration of dosage, dosing frequency or route of administration are required.

Patients with renal dysfunction:
No alteration of daily dosage or frequency of dosing, or route of administration is required.

Patients with hepatic impairment:
A total daily dose of 8 mg should not be exceeded.

 
:: WARNINGS AND PRECAUTIONS ::
  • Pregnancy (particularly first trimester of pregnancy) and breast-feeding women.
  • Children under 2 years old.
 
:: ADVERSE EFFECTS ::

Headache, constipation, sensation of warmth or flushing, sedation and diarrhea.

 
:: PRESENTATION ::

Box, 2 ampoules @ 4 ml.
2 ampoules @ 2 ml.